- December 6, 2024
- Category: Nuclear Medicine, Scientific Publications
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Dosimetric Evaluation of 177Lu Peptide Receptor Radionuclide Therapy Using GATE and Planet Dose
Ioanna Stamouli1, Thomas Nanos1, Konstantinos Chatzipapas2, Panagiotis Papadimitroulas3, Lydia-Aggeliki Zoglopitou4, Theodoros Kalathas4, Paraskevi F. Katsakiori1, Anna Makridou5 and George C. Kagadis1
1 3dmi Research Group, Department of Medical Physics, School of Medicine, University of Patras
26504 Rion, Greece; ioan.stamouli@gmail.com (I.S.); nanos@upatras.gr (T.N.); vkatsak@med.upatras.gr (P.F.K.)
2 Laboratoire de Traitement de l’Information Médicale (LaTIM), UMR1101, INSERM, Université de Bretagne
Occidentale, 29200 Brest, France; konstantinos.chatzipapas@univ-brest.fr
3 Bioemission Technology Solutions (BIOEMTECH), 11472 Athens, Greece; panpap@bioemtech.com
4 Nuclear Medicine Department, Cancer Hospital of Thessaloniki “Theagenio”, 54007 Thessaloniki, Greece
lzoglopi@gmail.com (L.-A.Z.); kalathas@dr.com (T.K.)
5 Medical Physics Department, Cancer Hospital Thessaloniki “Theagenio”, 54007 Thessaloniki, Greece
26504 Rion, Greece; ioan.stamouli@gmail.com (I.S.); nanos@upatras.gr (T.N.); vkatsak@med.upatras.gr (P.F.K.)
2 Laboratoire de Traitement de l’Information Médicale (LaTIM), UMR1101, INSERM, Université de Bretagne
Occidentale, 29200 Brest, France; konstantinos.chatzipapas@univ-brest.fr
3 Bioemission Technology Solutions (BIOEMTECH), 11472 Athens, Greece; panpap@bioemtech.com
4 Nuclear Medicine Department, Cancer Hospital of Thessaloniki “Theagenio”, 54007 Thessaloniki, Greece
lzoglopi@gmail.com (L.-A.Z.); kalathas@dr.com (T.K.)
5 Medical Physics Department, Cancer Hospital Thessaloniki “Theagenio”, 54007 Thessaloniki, Greece
ABSTRACT
This study aimed to compare the commercial dosimetric software Planet® Dose (version 3.1.1) from DOSIsoft and the open-source toolkit GATE. Dosimetry was performed for six patients receiving 200 mCi of Lutathera® every 8 weeks for four treatment cycles. For the dose calculation with Planet®, SPECT/CT images were acquired at 4, 24, 72 and 192 h post-injection. After the registration of all the time points to T0, the organs of interest (OOIs) were segmented. Time-activity curves were produced and the absorbed dose was calculated using the bi- and tri-exponential fitting methods. Regarding GATE simulations, the SPECT images of the 24 h time point were utilized for the radiopharmaceutical biodistribution in the OOIs and the attenuation maps were produced using the CT images. For liver and spleen, the average relative difference between GATE and Planet® was 9.6% and 11.1% for biexponential and 12.4% and 30.5% for triexponential fitting, respectively. The right and left kidneys showed differences up to 10.7% and 10.4% for the biexponential and up to 60.6% and 11.9% for the triexponential model, respectively. The absorbed dose calculated with GATE, Planet®(bi-exp) and Planet®(tri-exp) was in agreement with the literature. The results of the bi-exponential fitting were similar to the GATE-resulted calculations, while the tri-exponential fitting had a higher relative difference.