For the 1st time, DOSIsoft partipates in the 13th Argentinian Congress of Medical Physics and the 7th Latin American Congress on Medical Physics (ALFIM) from September 4th to 7th, 2016 in Córdoba, Argentina.
Product demonstration DOSIsoft presents its 3D dosimetry solutions for SIRT and Patient QA Software
Oral communication on Sunday, September 4th at 6pm, Marilyne KAFROUNI, PhD candidate in DOSIsoft
« 3D Dosimetry for Selective Internal Radiation Therapy of unresectable liver cancers using Yttrium-90 loaded Microspheres: Case Report »
« Dosimetría 3D en Radioembolización Hepática con microesferas cargadas con Ytrio-90: Reporte de Caso »
Today, in selective internal radiation therapy (SIRT), activity to inject is planned by standardized approaches that can be easily applied in everyday clinical workflow. However, interest for advanced dosimetry tools is growing since dose-effect relationship has been highlighted in the literature by different studies. This work aims at describing the implementation and potential of 3D voxel-based personalized dosimetry compared to standard approach. This is done through the report of a 68-year-old male patient with liver metastasis from colorectal carcinoma. A whole liver radioembolization using resin microspheres (SIR-Spheres®, SIRTeX, North Sydney, Australia) was performed with a narrow dose constraint of 30 Gy to non-tumoral liver (NTL) to preserve enough hepatic integrity. On one hand, the MIRD-based partition model, considered as standard approach, was applied on the uptake volume defined using Syngo®.via software solution (Siemens, Erlangen, Germany). On the other hand, both predictive and in vivo control dosimetries were carried out using a SIRT treatment planning system (TPS) (PLANET® Dose, DOSIsoft, Cachan, France) on anatomical volumes. The standard and TPS calculations estimated an average planned dose to NTL close to 30 Gy. Planned doses to the tumoral liver calculated by the partition model applied at the organ level and by the 3D TPS calculation at voxel level were 118 and 71 Gy respectively. Differences between both methods were partly related to the volume definition. Additional information provided by the TPS allowed to slightly adjust the activity to be injected delivering sufficient dose to tumoral liver while saving NTL as much as possible. In vivo dosimetry was performed on 90Y quantified PET images with the SIRT TPS and allowed to know the dose delivered to each region. This had an interest for the patient follow-up analysis and to consider later another possible treatment. SIRT TPS turned out to be a clinical decision-making tool thanks to the possible risk/benefit balance optimization. The study will be carried out with further patients to open the way to more personalized SIRT dosimetry.
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